Principal Investigators

  • Gregory J. Czarnota, PhD, MD

    Ph.D., MD, FRCPC, Senior Scientist

    Dr. Czarnota is conducting research focused on using ultrasound imaging and spectroscopy at conventional and high frequencies to detect apoptosis and other forms of cell death in response to chemotherapy and radiation therapy. He is also interested in the role of blood vessels in tumour radiation response and has also pioneered novel biophysical vascular destruction strategies that target tumour blood vessels.

  • Kullervo Hynynen, PhD

    Senior Scientist

    Education: • B.Sc., 1976, physics, University of Kuopio, Finland • M.Sc., 1977, physics, University of Kuopio, Finland • PhD, 1982, biomedical physics and biomedical engineering, University of Aberdeen, UK Appointments and Affiliations: Vice-president, research and innovation, Sunnybrook Health Sciences Centre Vice-president, research and innovation, Sunnybrook Research Institute Senior scientist, Physical Sciences, Odette Cancer Research Program, .. read more

  • Gregory Stanisz, PhD

    Ph.D., Senior Scientist

    Dr. Stanisz’s studies aim to develop magnetic resonance imaging (MRI) methods to improve specificity and sensitivity of noninvasive image methods in characterizing tissue pathology. His research team uses MRI in animal models of disease and in patients.

  • Michael C. Kolios, PhD

    Professor, Department of Physics

    Dr. Kolios is a physicist who's research primarily focuses on the source of scattering in ultrasound backscatter. His laboratory is multidisciplinary and uses state of the art ultrasound technology (conventional, high and ultra-high frequencies; acoustic microscopy), Optoacoustic Imaging / Optoacoustic microscopy. He is also interested in developing a better understanding of the use of microbubbles for Imaging and Therapy and the use of Optical Coherence Tomography in treatment monitoring.

  • David Goertz, PhD


    Dr. David Goertz is a scientist in Physical Sciences and a principal investigator in SRI’s focused ultrasound lab. His research focuses on understanding the basic behaviour of microbubble contrast agents in response to ultrasound to help develop new imaging techniques that will optimize the safety and efficacy of therapeutic applications. He is also studying the use .. read more

  • Ali Sadeghi-Naini, PhD


    The focus of Dr. Sadeghi-Naini's research is on developing computer-aided image-guided technologies to improve personalized cancer therapeutics. In particular, he is interested in developing integrated imaging and computational frameworks to detect and characterize cancer, to facilitate cancer-targeting interventions and to evaluate response to treatment.

  • Meaghan O’Reilly, PhD


    Education: • B.Sc., 2007, mechanical engineering, Queen’s University, Canada • M.Sc., 2008, biomedical engineering, University of Oxford, U.K. • PhD, 2012, applied physics, University of Eastern Finland, Finland  Appointments and Affiliations: Scientist,Physical Sciences, Holland Bone and Joint Research Program, Sunnybrook Research Institute Assistant professor, department of medical biophysics, University of Toronto Canada Research Chair in Biomedical .. read more

  • William Tran, PhD


    Education: • B.Sc., 2003, anatomy and cell biology, McGill University, Canada • M.Sc., 2011, radiotherapy and oncology, Sheffield Hallam University, U.K. • PhD, 2018, Sheffield Hallam University, U.K. • Research fellow, 2018, radiation oncology, University of Toronto, Canada Appointments and Affiliations: Scientist, Evaluative Clinical Sciences, Odette Cancer Research Program, Sunnybrook Research    Institute Staff radiation therapist, .. read more

  • Angus Lau, PhD


    Our aim is to develop and enhance the use of ultrasound techniques to improve cancer treatment. Our primary focus is the development of quantitative ultrasound (QUS) methods to monitor cancer therapy response. In addition, we have are developing novel ultrasound-based therapies to improve current conventional cancer treatments. Our ultimate goal is to implement both clinically at the end of the proposed research period, with clinical evaluations of enhanced imaging and cancer treatment derived from these research objectives.

  • Colleen Bailey, PhD

    Education PhD, 2012, Medical Biophysics, University of Toronto, Toronto, ON, Canada BSc, 2005, Biophysics, University of Guelph, Guelph, ON, Canada Appointments and Affiliations Scientist, Physical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute Adjunct Professor, Department of Physics, Faculty of Science, Ryerson University Assistant Professor, Department of Medical Biophysics, Faculty of Medicine, University of Toronto Senior Research .. read more

  • Alex Kiss, PhD

    Adjunct Scientist

    Education: PhD, 2003, Biostatistics, Columbia University, USA Appointments and Affiliations: Scientist, Evaluative Clinical Sciences, Hurvitz Brain Sciences Program, Sunnybrook Research Institute Assistant professor, Department of Health Policy, Management and Evaluation, University of Toronto Research Summary: Dr. Kiss’ research is focused on the design and analysis of studies ranging from clinical trials to observational studies, specializing .. read more