Principal Investigators

David Goertz, PhD

Sunnybrook Health Sciences Centre
2075 Bayview Avenue, Room C736B
Toronto, ON, M4N 3M5

Dr. David Goertz is a scientist in Physical Sciences and a principal investigator in SRI’s focused ultrasound lab. His research focuses on understanding the basic behaviour of microbubble contrast agents in response to ultrasound to help develop new imaging techniques that will optimize the safety and efficacy of therapeutic applications. He is also studying the use of microbubbles to enhance drug delivery and efficacy in tumours by examining vascular flow response to therapeutically stimulated microbubbles, and how it can be exploited to promote drug uptake. He is an associate professor in the department of medical biophysics at the University of Toronto.




  1. Pellow C, Cherin E, Abenojar EC, Exner AA, Zheng G, Demore CEM, Goertz DE. High-Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Jun;68(6):2059-2074. doi: 10.1109/TUFFC.2021.3055141. Epub 2021 May 25. PMID: 33513102; PMCID: PMC8296974.
  2. Pellow C, Tan J, Chérin E, Demore CEM, Zheng G, Goertz DE. High frequency ultrasound nonlinear scattering from porphyrin nanobubbles. Ultrasonics. 2021 Feb;110:106245. doi: 10.1016/j.ultras.2020.106245. Epub 2020 Sep 6. PMID: 32932144.


  1. Helfield BL, Yoo K, Liu J, Williams R, Sheeran PS, Goertz DE, Burns PN.Investigating the Accumulation of Submicron Phase-Change Droplets in Tumors. Ultrasound Med Biol. 2020 Oct;46(10):2861-2870. doi: 10.1016/j.ultrasmedbio.2020.06.021. Epub 2020 Jul 27. PMID: 32732167.
  2. Pellow C, Abenojar EC, Exner AA, Zheng G, Goertz DE. Concurrent visual and acoustic tracking of passive and active delivery of nanobubbles to tumors. Theranostics. 2020 Sep 23;10(25):11690-11706. doi: 10.7150/thno.51316. PMID: 33052241; PMCID: PMC7545999.
  3. Santos MA, Wu SK, Regenold M, Allen C, Goertz DE, Hynynen K. Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs. Sci Adv. 2020 Sep 2;6(36):eaba5684. doi: 10.1126/sciadv.aba5684. PMID: 32917589; PMCID: PMC7467687.
  4. Munding CE, Chérin E, Alves N, Goertz DE, Courtney BK, Foster FS. 30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging./80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging. Ultrasound Med Biol. 2020 Aug;46(8):2104-2112. doi: 10.1016/j.ultrasmedbio.2020.03.032. Epub 2020 May 27. PMID: 32473846.
  5. Pellow C, O’Reilly MA, Hynynen K, Zheng G, Goertz DE. Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation. Nano Lett. 2020 Jun 10;20(6):4512-4519. doi: 10.1021/acs.nanolett.0c01310. Epub 2020 May 8. PMID: 32374617.


  1. Acconcia CN, Leung BYC, Winch G, Wang J, Hynynen K, Goertz DE. Acoustic radiation force induced accumulation and dynamics of microbubbles on compliant surfaces. Phys Med Biol. 2019 Jul 2;64(13):135003. doi: 10.1088/1361-6560/ab2163. PubMed PMID: 31082815.


  1.  Acconcia CN, Wright A, Goertz DE. Translational dynamics of individual microbubbles with millisecond scale ultrasound pulses. J Acoust Soc Am. 2018 Nov;144(5):2859. doi: 10.1121/1.5063353. PubMed PMID: 30522286.
  2.  Bulner S, Prodeus A, Gariepy J, Hynynen K, Goertz DE. Enhancing Checkpoint Inhibitor Therapy with Ultrasound Stimulated Microbubbles. Ultrasound Med Biol. 2019 Feb;45(2):500-512. doi: 10.1016/j.ultrasmedbio.2018.10.002. Epub 2018 Nov 15. PubMed PMID: 30447880
  3. Pellow C, Goertz DE, Zheng G. Breaking free from vascular confinement: status and prospects for submicron ultrasound contrast agents. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Jul;10(4):e1502. doi: 10.1002/wnan.1502. Epub 2017 Nov 17. Review. PubMed PMID: 29148219.


  1. Santos MA, Goertz DE, Hynynen K. Focused Ultrasound Hyperthermia Mediated Drug Delivery Using Thermosensitive Liposomes and Visualized With in vivo Two-Photon Microscopy. Theranostics. 2017 Jul 7;7(10):2718-2731. doi: 10.7150/thno.19662.eCollection 2017. PubMed PMID: 28819458; PubMed Central PMCID: PMC5558564.
  2. Acconcia CN, Jones RM, Goertz DE, O’Reilly MA, Hynynen K. Megahertz rate, volumetric imaging of bubble clouds in sonothrombolysis using a sparse hemispherical receiver array. Phys Med Biol. 2017 Sep 5;62(18):L31-L40. doi: 10.1088/1361-6560/aa84d7. PubMed PMID: 28786395.