Principal Investigators

Michael C. Kolios, PhD

Professor, Department of Physics
Associate Dean of Science,
Research and Graduate Studies
Faculty of Science Office:
Rm VIC-733:
285 Victoria Street,
Toronto, ON
M5B 2K3

Education:

PhD., Medical Physics, Department of Medical Biophysics, U of Toronto 1998
M.Sc., Medical Physics, Department of Medical Biophysics, U of Toronto 1994
B.Sc. Physics, (Minor: Computer Science), Department of Physics, U of Waterloo 1991

Appointments and Affiliations:

Associate Professor, Department of Physics (prior Mathematics, Physics and Computer Science), Ryerson University
Adjunct Professor, Department of Medical Biophysics, Full Member School Graduate Studies, University of Toronto
Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
Canada Research Chair, TierII, Biomedical Applications of Ultrasound
Graduate Program in Physics, in the field of Biomedical Physics, Ryerson University

Research Focus:

Specialization:

Ultrasound imaging and therapeutics, Ultrasound imaging, Optical Coherence Tomography, Photoacoustics, Theranostic agent development, Heat transfer in tissue, Thermal Therapies

Research Projects:

My research interests are in the application of ultrasound in medicine and the modeling of heat transfer in tissues. I am currently examining the potential of using high frequency ultrasound imaging (20-60MHz) for the detection of cell death. Even though at these frequencies we cannot resolve individual cells, we can examine the ultrasound backscatter from cell ensembles to make inferences about the state of the cells. We have found that the ultrasound backscatter from cells dying either by apoptosis (a form of cell suicide) or necrosis increases, and the frequency dependence of the backscatter power spectra can potentially be used to differentiate between the two, at least in the in vitro systems we have used to date. I am collaborating with researchers at the Sunybrook Hospital in Toronto to determine whether this methodology can also be used in animal tumor models (to detect the death of cancer cells), and we are currently participating in a clinical trial involving cancer patients with superficial tumors. We have developed theoretical models to better understand the backscattering process, and have used experimental systems to examine the backscatter from objects on the scale of cells for which we know their properties. Ultrasonic characterization of cells and cellular components is thus an ongoing interest in the lab. Ultrasound at higher intensities can be used to destroy tissues rather than image them. We have developed theoretical models to estimate temperatures during the heating of tissue using ultrasound or other sources (such as laser), and are currently examining the effect of blood flow on these heating patterns. Furthermore I am investigating the use of an acoustic camera to monitor the treated tissue non-invasively. The acoustic camera records how ultrasound is attenuated rather than detecting the backscatter as conventional ultrasound does. Finally, I have incorporated in my research program optical techniques as a source of new contrast: optical coherence tomography and photoacoustic imaging, which currently form a substantial core of my research program.

 

Publications:

2021

  1. Wang Y, Fadhel MN, Hysi E, Pastenak M, Sathiyamoorthy K, Kolios MC. In vivo spectroscopic photoacoustic imaging and laser-induced nanoparticle vaporization for anti-HER2 breast cancer. J Biophotonics. 2021 Jul 9:e202100099. doi: 10.1002/jbio.202100099.  PMID: 34241969
  2. Wang Y, Pasternak M, Sathiyamoorthy K, Kolios MC. Anti-HER2 PLGA-PEG polymer nanoparticle containing gold nanorods and paclitaxel for laser-activated breast cancer detection and therapy. Biomed Opt Express. 2021 Mar 18;12(4):2171-2185. doi: 10.1364/BOE.419252. eCollection 2021 Apr 1. PMID: 33996222
  3. Fernandes DA, Fernandes DD, Malik A, Gomes GW, Appak-Baskoy S, Berndl E, Gradinaru CC, Kolios MC. Multifunctional nanoparticles as theranostic agents for therapy and imaging of breast cancer. J Photochem Photobiol B. 2021 May;218:112110. doi:10.1016/j.jphotobiol.2020.112110. Epub 2020 Dec 29. PMID: 33865007
  4. Xu J, Salari A, Wang Y, He X, Kerr L, Darbandi A, de Leon AC, Exner AA, Kolios MC, Yuen D, Tsai SSH. Microfluidic Generation of Monodisperse Nanobubbles by Selective Gas Dissolution.Small. 2021 Apr 2:e2100345. doi: 10.1002/smll.202100345.  PMID: 33811441
  5.  Salari A, Appak-Baskoy S, Coe IR, Abousawan J, Antonescu CN, Tsai SSH, Kolios MC. Dosage-controlled intracellular delivery mediated by acoustofluidics for lab on a chip applications. Lab Chip. 2021 May 4;21(9):1788-1797. doi: 10.1039/d0lc01303j. PMID: 33734246
  6. Osapoetra LO, Sannachi L, Quiaoit K, Dasgupta A, DiCenzo D, Fatima K, Wright F, Dinniwell R, Trudeau M, Gandhi S, Tran W, Kolios MC, Yang W, Czarnota GJ. A priori prediction of response in multicentre locally advanced breast cancer (LABC) patients using quantitative ultrasound and derivative texture methods.Oncotarget. 2021 Jan 19;12(2):81-94. doi: 10.18632/oncotarget.27867. eCollection 2021 Jan 19. PMID: 33520113
  7. Sojahrood AJ, Haghi H, Shirazi NR, Karshafian R, Kolios MC. On the threshold of 1/2 order subharmonic emissions in the oscillations of ultrasonically excited bubbles. Ultrasonics. 2021 Apr;112:106363. doi: 10.1016/j.ultras.2021.106363. Epub 2021 Jan 20. PMID: 33508558
  8.  Sojahrood AJ, Haghi H, Karshafian R, Kolios MC. Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles.Ultrason Sonochem. 2021 Apr;72:105405. doi: 10.1016/j.ultsonch.2020.105405. Epub 2020 Dec 8. PMID: 33360533
  9. Assi H, Yang C, Shaswary E, Tam M, Tavakkoli J, Kolios M, Peyman G, Kumaradas C.Real-Time Control of Nanoparticle-Mediated Thermal Therapy Using Photoacoustic Imaging. IEEE Trans Biomed Eng. 2021 Jul;68(7):2188-2194. doi: 10.1109/TBME.2020.3037991. Epub 2021 Jun 17. PMID: 33186098

2020

  1. Salari A, Appak-Baskoy S, Ezzo M, Hinz B, Kolios MC, Tsai SSH. Dancing with the Cells Acoustic Microflows Generated by Oscillating Cells. Small. 2020 Aug;16(33):e2004323. doi: 10.1002/smll.202004323. Epub 2020 Jul 26. PMID: 33439539
  2. Moore MJ , Bodera F , Hernandez C , Shirazi N , Abenojar E , Exner AA , Kolios MC . The dance of the nanobubbles- detecting acoustic backscatter from sub-micron bubbles using ultra-high frequency acoustic microscopy. Nanoscale. 2020 Nov 7;12(41):21420-21428. doi: 10.1039/d0nr05390b. Epub 2020 Oct 20. PMID: 33079108
  3. Fadhel MN, Appak Baskoy S, Wang Y, Hysi E, Kolios MC. J Biophotonics. Use of photoacoustic imaging for monitoring vascular disrupting cancer treatments.2020 Sep 5:e202000209. doi: 10.1002/jbio.202000209.  PMID: 32888381
  4. Doan M, Sebastian JA, Caicedo JC, Siegert S, Roch A, Turner TR, Mykhailova O, Pinto RN, McQuin C, Goodman A, Parsons MJ, Wolkenhauer O, Hennig H, Singh S, Wilson A, Acker JP, Rees P, Kolios MC, Carpenter AE. Objective assessment of stored blood quality by deep learning. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21381-21390. doi: 10.1073/pnas.2001227117. Epub 2020 Aug 24. PMID: 32839303
  5. Hysi E, Fadhel MN, Wang Y, Sebastian JA, Giles A, Czarnota GJ, Exner AA, Kolios MC. Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment Photoacoustics. 2020 Jul 25;20:100201. doi: 10.1016/j.pacs.2020.100201. eCollection 2020 Dec. PMID: 32775198
  6. Fadhel MN, Hysi E, Assi H, Kolios MC. Fluence-matching technique using photoacoustic radiofrequency spectra for improving estimates of oxygen saturation.Photoacoustics. 2020 May 24;19:100182. doi: 10.1016/j.pacs.2020.100182. eCollection 2020 Sep. PMID: 32547922
  7. Jeganathan S, Budziszewski E, Bielecki P, Kolios MC, Exner AA. In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors. J Control Release. 2020 Aug 10;324:146-155. doi: 10.1016/j.jconrel.2020.05.003. Epub 2020 May 7. PMID: 32389777
  8. de Leon A, Wei P, Bordera F, Wegierak D, McMillen M, Yan D, Hemmingsen C, Kolios MC, Pentzer EB, Exner AA. Pickering Bubbles as Dual-Modality Ultrasound and Photoacoustic Contrast Agents.ACS Appl Mater Interfaces. 2020 May 13;12(19):22308-22317. doi: 10.1021/acsami.0c02091. Epub 2020 May 1. PMID: 32307987
  9. Sojahrood AJ, Haghi H, Karshafian R, Kolios MC. Critical corrections to models of nonlinear power dissipation of ultrasonically excited bubbles. Ultrason Sonochem. 2020 Sep;66:105089. doi: 10.1016/j.ultsonch.2020.105089. Epub 2020 Mar 24. PMID: 32252009
  10. Nasr R, Falou O, Shahin A, Hysi E, Wirtzfeld LA, Berndl ESL, Kolios MC. Mean Scatterer Spacing Estimation Using Cepstrum-Based Continuous Wavelet Transform.IEEE Trans Ultrason Ferroelectr Freq Control. 2020 Jun;67(6):1118-1126. doi: 10.1109/TUFFC.2020.2963955. Epub 2020 Jan 6. PMID: 31905136

2019

  1. Alnazer I, Falou O, Nasr R, Azar D, Hysi E, Wirtzfeld L, Berndl ESL, Kolios MC. Quantitative Ultrasound Imaging for the Differentiation between Fresh and Decellularized Mouse Kidneys. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:6624-6627. doi: 10.1109/EMBC.2019.8856518. PMID: 31947360
  2. Zalev J, Richards LM, Clingman BA, Harris J, Cantu E, Menezes GLG, Avila C, Bertrand A, Saenz X, Miller S, Oraevsky AA, Kolios MC. Opto-acoustic imaging of relative blood oxygen saturation and total hemoglobin for breast cancer diagnosis.J Biomed Opt. 2019 Dec;24(12):1-16. doi: 10.1117/1.JBO.24.12.121915. PMID: 31849204
  3. Fadhel MN, Hysi E, Zalev J, Kolios MC. Photoacoustic simulations of microvascular bleeding: spectral analysis and its application for monitoring vascular-targeted treatments. J Biomed Opt. 2019 Nov;24(11):1-8. doi: 10.1117/1.JBO.24.11.116001. PMID: 31707772
  4. Sathiyamoorthy K, Kolios MC. Experimental design and numerical investigation of a photoacoustic sensor for a low-power, continuous-wave, laser-based frequency-domain photoacoustic microscopy.J Biomed Opt. 2019 Oct;24(12):1-12. doi: 10.1117/1.JBO.24.12.121912. PMID: 31674163
  5. Maraghechi B, Kolios MC, Tavakkoli J. Feasibility of detecting change in backscattered energy of acoustic harmonics in locally heated tissues.Int J Hyperthermia. 2019;36(1):964-974. doi: 10.1080/02656736.2019.1660001. PMID: 31542971
  6. Haghi H, Sojahrood AJ, Kolios MC. Collective nonlinear behavior of interacting polydisperse microbubble clusters.  Ultrason Sonochem. 2019 Nov;58:104708. doi: 10.1016/j.ultsonch.2019.104708. Epub 2019 Jul 24. PMID: 31450322
  7. de Leon A, Perera R, Hernandez C, Cooley M, Jung O, Jeganathan S, Abenojar E, Fishbein G, Sojahrood AJ, Emerson CC, Stewart PL, Kolios MC, Exner AA.Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles. Nanoscale. 2019 Sep 7;11(33):15647-15658. doi: 10.1039/c9nr04828f. Epub 2019 Aug 13. PMID: 31408083
  8. Pinto RN, Hysi E, Bagga K, Sebastian JA, Douplik A, Acker JP, Kolios MC.Feasibility of photoacoustic imaging for the non-invasive quality management of stored blood bags.  Vox Sang. 2019 Oct;114(7):701-710. doi: 10.1111/vox.12828. Epub 2019 Aug 7. PMID: 31392743
  9. Hysi E, Fadhel MN, Moore MJ, Zalev J, Strohm EM, Kolios MC. Insights into photoacoustic speckle and applications in tumor characterization.  Photoacoustics. 2019 Apr 5;14:37-48. doi: 10.1016/j.pacs.2019.02.002. eCollection 2019 Jun. PMID: 31080733
  10. Liang B , Yu K , Ling Y , Kolios M , Exner A , Wang Z , Hu B , Zuo G , Chen Y , Zheng Y .An artificially engineered “tumor bio-magnet” for collecting blood-circulating nanoparticles and magnetic hyperthermia.  Biomater Sci. 2019 Apr 23;7(5):1815-1824. doi: 10.1039/c8bm01658e. PMID: 30916668
  11. Sojahrood AJ, Wegierak D, Haghi H, Karshfian R, Kolios MC. A simple method to analyze the super-harmonic and ultra-harmonic behavior of the acoustically excited bubble oscillator.  Ultrason Sonochem. 2019 Jun;54:99-109. doi: 10.1016/j.ultsonch.2019.02.010. Epub 2019 Feb 13.PMID: 30827907
  12. Hernandez C , Abenojar EC , Hadley J , de Leon AC , Coyne R , Perera R , Gopalakrishnan R , Basilion JP , Kolios MC , Exner AA .Sink or float? Characterization of shell-stabilized bulk nanobubbles using a resonant mass measurement technique.  Nanoscale. 2019 Jan 17;11(3):851-855. doi: 10.1039/c8nr08763f. PMID: 30601524

2017

  1. Amihai Meiri, Eric M. Strohm, Michael C. Kolios, Zeev Zalevsky (2017) Spatial interference encoding patterns based photoacoustic microscopy Optics Communications, Volume 401, 15 October 2017, Pages 23-28 https://doi.org/10.1016/j.optcom.2017.05.002
  2. Krishnan Sathiyamoorthy, Eric M. Strohm and Michael C. Kolios (2017) Low-power noncontact photoacoustic microscope for bioimaging applications J. Biomed. Opt. 22(4), 046001 (Apr 04, 2017).http://doi.org/10.1117/1.JBO.22.4.046001
  3. Vaskar Gnyawali, Mohammadali Saremi, Michael C. Kolios, and   Scott S. H. Tsai (2017) Stable microfluidic flow focusing using hydrostatics Biomicrofluidics 11, 034104 (2017); doi: http://dx.doi.org/10.1063/1.4983147
  4. Vaskar Gnyawali, Byeong-Ui Moon, Jennifer Kieda, Raffi Karshafian, Michael C. Kolios and  Scott S. H. Tsai (2017)Honey, I shrunk the bubbles: microfluidic vacuum shrinkage of lipid-stabilized microbubbles
    Soft Matter, 2017, http://dx.doi.org/10.1039/c7sm00128b https://rsc.altmetric.com/details/18532311
  5. Eno Hysi, Lauren A. Wirtzfeld, Jonathan P. May, Elijus Undzys, Shyh-Dar Li, Michael C. Kolios (2017) Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation Photoacoustics Volume 5, March 2017, Pages 25–35 http://doi.org/10.1016/j.pacs.2017.03.003
  6. Maurice Pasternak, Lilian Doss, Golnaz Farhat, Azza Al-Mahrouki, Christina Hyunjung Kim, Michael Kolios, William Tyler Tran, Gregory J. Czarnota (2017) Effect of chromatin structure on quantitative ultrasound parameters Oncotarget. ; 8:19631-19644. http://doi.org/10.18632/oncotarget.14816
  7. Ratan K Saha, Subhajit Karmakar, Arunabha Adhikari and Michael C Kolios (2017) Photoacoustic field calculation for nonspherical axisymmetric fluid particles Biomedical Physics & Engineering Express, Volume 3, Number 1 015017 https://doi.org/10.1088/2057-1976/aa555f

2016

  1. May JP, Hysi E, Wirtzfeld LA, Undzys E, Li S-D, Kolios MC(2016) Photoacoustic Imaging of Cancer Treatment Response: Early Detection of Therapeutic Effect from Thermosensitive Liposome PLoS ONE 11(10): e0165345. http://dx.doi.org/10.1371/journal.pone.0165345
  2. M.J. Moore, E. M. Strohm and M. C. Kolios (2016) Assessment of the Nucleus-to-Cytoplasmic Ratio in MCF-7 Cells Using Ultra-high Frequency Ultrasound and Photoacoustics Int J Thermophys  (2016) 37:118 http:dx.doi.org/10.1007/s10765-016-2129-y
  3. Yang Zhou, Ronghui Wang, Zhaogang Teng, Zhigang Wang, Bing Hu, Michael Kolios, Hangrong Chen, Nan Zhang, Yanjie Wang, Pan Li, Xing Wu, Guangming Lu, Yu Chen and Yuanyi Zheng (2016) Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics NPG Asia Materials (2016) 8, e313; http://dx.doi.org/10.1038/am.2016.14
  4. Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods Yanjie Wang, Eric M. Strohm, Yang Sun, Zhaoxia Wang, Yuanyi Zheng, Zhigang Wang, and Michael C. Kolios (2016)
    Biomedical Optics Express Vol. 7, Issue 10, pp. 4125-4138 (2016) http://dx.doi.org/10.1364/BOE.7.004125
  5. Maurice M. Pasternak, Ali  Sadeghi-Naini, Shawn M. Ranieri, Anoja  Giles, Michael L. Oelze, Michael C. Kolios and Gregory J. Czarnota (2016) High-frequency ultrasound detection of cell death: Spectral differentiation of different forms of cell death in vitro Oncoscience  http://dx.doi.org/10.18632/oncoscience.319
  6. Donald Anthony Fernandes, Dennis Denzil Fernandes, Yuchong Li, Yan Wang, Zhenfu Zhang, Dérick Rousseau, Claudiu C Gradinaru, and Michael C. Kolios (2016) Synthesis Of Stable Multifunctional Perfluorocarbon Nanoemulsions For Cancer Therapy And Imaging Langmuir, Just Accepted Manuscript http://dx.doi.org/10.1021/acs.langmuir.6b01867
  7. Ping Gong, Michael C. Kolios, Yuan Xu (2016) Pseudo-Inverse (PI) Decoding process in Delay encoded Synthetic Transmit Aperture (DE-STA) Imaging IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control  vol. 63, no. 9, pp. 1372-1379, Sept. 2016. http://dx.doi.org/10.1109/TUFFC.2016.2578952
  8. Tae-Hoon Bok, Eno Hysi, and Michael C. Kolios (2016) Simultaneous assessment of red blood cell aggregation and oxygen saturation under pulsatile flow using high-frequency photoacoustics
    Biomedical Optics Express July 2016 Volume 7(7) #262587 http://dx.doi.org/10.1364/BOE.7.002769
  9. Eric M. Strohm, Michael J. Moore, Michael C. Kolios (2016) Single cell photoacoustic microscopy: a review
    IEEE Journal of Selected Topics in Quantum Electronics Volume 22, Issue 3, May-June 2016 http://dx.doi.org/10.1109/JSTQE.2015.2497323
  10. Borna Maraghechi, Mojtaba H. Hasani, Michael C. Kolios, and Jahan Tavakkoli (2016) Temperature dependence of acoustic harmonics generated by nonlinear ultrasound wave propagation in water at various frequencies Journal of the Acoustical Society of America 139, 2475  http://dx.doi.org/10.1121/1.4946898
  11. Eric M. Strohm, Michael J. Moore, Michael C. Kolios (2016) High resolution ultrasound and photoacoustic imaging of single cells
    Photoacoustics Volume 4, Issue 1, March 01, 2016, Pages 36-42 http://dx.doi.org/10.1016/j.pacs.2016.01.001
  12. Maurice M. Pasternak, Lauren A. Wirtzfeld, Michael C. Kolios and Gregory J. Czarnota (2016) High-frequency ultrasound analysis of post-mitotic arrest cell death Oncoscience  http://dx.doi.org/10.18632/oncoscience.301

2015

  1. Hadi Tadayyon, Lakshmanan Sannachi, Ali Sadeghi-Naini, Azza Al-Mahrouki, William T. Tran, Michael C. Kolios, Gregory J. Czarnota (2015) Quantification of Ultrasonic Scattering Properties of In Vivo Tumor Cell Death in Mouse Models of Breast Cancer Translational Oncology 8(6) pp. 463–473 http://dx.doi.org/10.1016/j.tranon.2015.11.001
  2. Golnaz Farhat, Anoja Giles, Michael C. Kolios, Gregory J. Czarnota (2015) Optical coherence tomography spectral analysis for detecting apoptosis in vitro and in vivo Journal of Biomedical Optics 20(12), 126001 http://dx.doi.org/10.1117/1.JBO.20.12.126001
  3. Ping Gong, Michael C. Kolios, and Yuan Xu (2015) Delay-Encoded Transmission and Image Reconstruction Method in Synthetic  Transmit Aperture Imaging IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Oct. 62(10):  1745 – 1756  http://dx.doi.org/10.1109/TUFFC.2015.007005
  4. Pasternak MM, Strohm EM, Berndl ES, Kolios MC. (2015) Properties of Cells through Life and Death – An Acoustic Microscopy Investigation Cell Cycle.  Jul 15:0. [Epub ahead of print] http://dx.doi.org/10.1080/15384101.2015.1069925
  5. Fadhel MN, Berndl ES, Strohm EM, Kolios MC. (2015) High-Frequency Acoustic Impedance Imaging of Cancer Cells. Ultrasound in Medicine and  Biology Jul 9. pii: S0301-5629(15)00400-7. http://dx.doi.org/10.1016/j.ultrasmedbio.2015.06.003
  6. Maraghechi B, Kolios MC, Tavakkoli J. (2015) Temperature dependence of acoustic harmonics generated by nonlinear ultrasound beam propagation in ex vivo tissue and tissue-mimicking phantoms. International Journal of Hyperthermia Jul 1:1-8. [Epub ahead of print] http://dx.doi.org/10.3109/02656736.2015.1052856
  7. Strohm EM, Kolios MC. (2015) Classification of blood cells and tumor cells using label-free ultrasound and photoacoustics. Cytometry A. Jun 16. http://dx.doi.org/10.1002/cyto.a.22698. [Epub ahead of print]
  8. Jason Zalev and Michael C. Kolios (2015) Exact solution for a photoacoustic wave from a finite-length cylindrical source Journal of the Acoustical Society of  America 137 (4), Pages: 1675–1682 DOI: http://dx.doi.org/10.1121/1.4916273
  9. Ali Sadeghi-Naini, Ervis Sofroni, Naum Papanicolau, Omar Falou, Linda Sugar, Gerard Morton, Martin J. Yaffe, Robert Nam, Alireza Sadeghian, Michael C. Kolios, Hans T. Chung, Gregory J. Czarnota (2015) Quantitative Ultrasound Spectroscopic Imaging for Characterization of Disease Extent in Prostate Cancer Patients Translational Oncology Volume 8, Issue 1, Pages 25–34 DOI: http://dx.doi.org/10.1016/j.tranon.2014.11.005
  10. Amin Jafari Sojahrood, Omar Falou, Robert Earl, Raffi Karshafian, Michael C. Kolios (2015) Influence of the pressure-dependent resonance frequency on the bifurcation structure and backscattered pressure of ultrasound contrast agents: a numerical investigation Nonlinear Dynamics  1-16   –  DOI: 10.1007/s11071-015-1914-7

2014

  1. Yang Sun, Yanjie Wang, Chengcheng Niu, Eric M. Strohm, Yuanyi Zheng, Haitao Ran, Rongzhong Huang, Di Zhou, Yuping Gong, Zhigang Wang, Dong Wang and Michael C. Kolios (2014) Laser-Activatible PLGA Microparticles for Image-Guided Cancer Therapy In Vivo Advanced Functional Materials  –  DOI: 10.1002/adfm.201402631 (commentary: Cancer treatment based on PLGA microparticles, – Materials Views – posted October 2014)
  2. Eric M Strohm, Ivan Gorelikov, Naomi Matsuura and Michael C Kolios (2014) Modeling photoacoustic spectral features of micron-sized particles Physics in Medicine & Biology 59  5795–5810
  3. Mikhail Yu. Kirillin, Golnaz Farhat, Ekaterina A. Sergeeva, Michael C. Kolios, and Alex Vitkin (2014) Speckle statistics in OCT images: Monte Carlo simulations and experimental studiesOptics Letters 39(2)  3472-3475
  4. Michelle P. Patterson, Christopher B. Riley, Michael C. Kolios, William M. Whelan (2014) Optoacoustic characterization of prostate cancer in an in vivo transgenic murine model J. Biomed. Opt. 19(5), 056008 (May 09, 2014). doi:10.1117/1.JBO.19.5.056008
  5. Ali Sadeghi-Naini, Lakshmanan Sannachi, Kathleen Pritchard, Maureen Trudeau, Sonal Gandhi, Frances C. Wright, Judit Zubovits, Martin J. Yaffe, Michael C. Kolios, Gregory J. Czarnota (2014) Early prediction of therapy responses and outcomes in breast cancer patients using textural characteristics of quantitative ultrasound spectral parametric maps Oncotarget (5)
  6. Mosa Alhamami, Michael C. Kolios, and Jahan Tavakkoli (2014) Photoacoustic detection and optical spectroscopy of HIFU lesions Medical Physics 41, 053502 (2014); doi: 10.1118/1.4871621
  7. Marjan Razani, Timothy W.H. Luk, Adrian Mariampillai, Peter Siegler, Tim-Rasmus Kiehl, Michael C. Kolios, and Victor X.D. Yang (2014) Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples Biomedical Optics Express,  March 2014, Vol. 5 No.3,   doi:10.1364/BOE.5.000895
  8. Lakshmanan Sannachi, Hadi Tadayyon, Ali Sadeghi-Naini, Michael C. Kolios, Gregory Czarnota (2014) Personalization of breast cancer chemotherapy using noninvasive imaging methods to detect tumor cell death responses Breast Cancer Management, January 2014, Vol. 3, No. 1, Pages 31-35

2013

  1. Eric M. Strohm, Elizabeth S. L. Berndl, and Michael C. Kolios (2013) High frequency label-free photoacoustic microscopy of single cells Photoacoustics Volume 1, Issues 3-4
  2. Eric M. Strohm, Elizabeth S. L. Berndl, and Michael C. Kolios (2013) Probing Red Blood Cell Morphology Using High-Frequency Photoacoustics Biophysical Journal Volume 105 1–9https://cell.altmetric.com/details/1600902 (see also press coverage: http://www.physics.ryerson.ca/node/1769)
  3. Ali Sadeghi-Naini, Naum Papanicolau, Omar Falou, Hadi Tadayyon, Justin Lee, Judit Zubovits, Raffi Karshafian, Azza Al-Mahrouki, Anoja Giles, Michael C. Kolios and Gregory J. Czarnota (2013)  Low-frequency quantitative ultrasound imaging of cell death in vivo Medical Physics 40 (8)
  4. Kaleigh Briggs, Azza Al Mahrouki, Joris Nofiele, Ahmad El-Falou, Martin Stanisz. Hyunjung Christina Kim, Michael C. Kolios, Gregory J. Czarnota (2013)Non-invasive Monitoring of Ultrasound-Stimulated Microbubble Radiation Enhancement Using Photoacoustic Imaging TCRT Express 1(2) 143-152 (e600266)
  5. Ali Sadeghi-Naini, Omar Falou, Hadi Tadayyon, Azza Al-Mahrouki, William Tran, Naum Papanicolau, Michael C Kolios, Gregory J Czarnota (2013) Conventional frequency ultrasonic biomarkers of cancer treatment response in vivo Translational Oncology 6 (3) 234-243
  6. Ali Sadeghi-Naini, Naum Papanicolau, Omar Falou, Judit Zubovits, Rebecca Dent, Sunil Verma, Maureen E. Trudeau, Jean Francois Boileau, Jacqueline Spayne, Sara Iradji, Ervis Sofroni, Justin Lee, Sharon Lemon-Wong, Martin J Yaffe, Michael C. Kolios, and Gregory J. Czarnota (2013) Quantitative Ultrasound Evaluation of Tumour Cell Death Response in Locally Advanced Breast Cancer Patients Receiving Chemotherapy Clinical Cancer Research 19 (8) 2163-2174
  7. Ahmed El Kaffas, Devesh Bekah, Min Rui, J Carl Kumaradas and Michael C Kolios (2013) Investigating longitudinal changes in the mechanical properties of MCF-7 cells exposed to paclitaxol using particle tracking microrheologyPhysics in Medicine and Biology 58 (2013) 923–936(commentary: Cell elasticity indicates therapy response – Medical Physics Web – posted Feb 2013)

2012

  1. Eno Hysi, Ratan K. Saha and Michael C. Kolios (2012) Photoacoustic ultrasound spectroscopy for assessing red blood cell aggregation and oxygenation Journal of Biomedical Optics 17(12), 125006
  2. Eric M. Strohm, Ivan Gorelikov, Naomi Matsuura, Michael C. Kolios (2012) Acoustic and photoacoustic characterization of micron-sized perfluorocarbon emulsionsJournal of Biomedical Optics 17(9), 096016
  3. Omar Falou, Amin Jafari Sojahrood, J. Carl Kumaradas, and Michael C. Kolios (2012) Surface modes and acoustic scattering of microspheres and ultrasound contrast agents The Journal of the Acoustical Society of America 133 (5)  – 1820-1829
  4. Eno Hysi, Ratan K. Saha and Michael C. Kolios (2012)On the use of photoacoustics to detect red blood cell aggregationBiomedical Optics Express, Vol. 3, No. 9, Pages 2326-2338
  5. Ali Sadeghi-Naini, Omar Falou, John M Hudson, Colleen Bailey, Peter N Burns, Martin J Yaffe, Greg J Stanisz, Michael C Kolios & Gregory J Czarnota (2012) Imaging innovations for cancer therapy response monitoring Imaging in Medicine, Voume 4 Number 3 , Pages  311-327
  6. Lee J, Karshafian R, Papanicolau N, Giles A, Kolios MC, Czarnota GJ. (2012) Quantitative Ultrasound for the Monitoring of Novel Microbubble and Ultrasound Radiosensitization Ultrasound in Medicine and Biology Volume 38, Issue 7, Pages 1212–1221
  7. Amin Jafari Sojahrood and Michael C. Kolios (2012) Classification of the nonlinear dynamics and bifurcation structure of ultrasound contrast agents excited at higher multiples of their resonance frequency Physics Letters A, Volume 376, Issue 33 pp. 2222–2229
  8. Ratan K. Saha, Subhajit Karmakar, Eno Hysi, Madhusudan Roy, and Michael C. Kolios (2012) Validity of a theoretical model to examine blood oxygenation dependent optoacoustics Journal of Biomedical Optics 17(5), 055002
  9. Marjan Razani, Adrian Mariampillai, Cuiru Sun, Timothy W. H. Luk, Victor X. D. Yang, and Michael C. Kolios (2012) Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms
    Biomedical Optics Express, Vol. 3, Issue 5, pp. 972-980

2011

  1. Ratan K. Saha and Michael C. Kolios (2011)  Effects of erythrocyte oxygenation on optoacoustic signals Journal of Biomedical Optics 16, 115003; doi:10.1117/1.3655355
  2. Golnaz Farhat, Adrian Mariampillai, Victor X. D. Yang, Gregory J. Czarnota and Michael C. Kolios (2011), Detecting apoptosis using dynamic light scattering with optical coherence tomography Journal of Biomedical Optics 16, 070505 (Jul 18, 2011); doi:10.1117/1.3600770
  3. Ratan K. Saha and Michael C. Kolios (2011) Effects of Cell Spatial Organization and Size Distribution on Ultrasound Backscattering IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol.58(10)  2118-2131
  4. Ratan K. Saha and Michael C. Kolios (2011) A simulation study on photoacoustic signals from red blood cellsThe Journal of the Acoustical Society of America 129 (5)  – 2935–2943[URL: http://link.aip.org/link/?JAS/129/2935 – DOI: 10.1121/1.3570946]
  5. Eric Strohm, Min Rui, Ivan Gorelikov, Naomi Matsuura, and Michael Kolios (2011) Vaporization of perfluorocarbon droplets using optical irradiation Biomedical Optics Express, Vol. 2, Issue 6, pp. 1432-1442
  6. Golnaz Farhat, Victor X. D. Yang, Gregory J. Czarnota and Michael C. Kolios (2011) Detecting cell death with optical coherence tomography and envelope statisticsJournal of Biomedical Optics 16(2) – 026017
  7. Adam J. Shuhendler, Preethy Prasad, Ho-Ka Carol Cha†, Claudia R. Gordijo, Behrouz Soroushian, Michael Kolios, Kui Yu, Peter J. O’Brien, Andrew Michael Rauth, and Xiao Yu Wu (2011) Hybrid Quantum Dot−Fatty Ester Stealth Nanoparticles: Toward Clinically Relevant in Vivo Optical Imaging of Deep Tissue ACS Nano 5(3) – 1958-1966

2010

  1. -Behrouz Soroushian, William M. Whelan, Michael C. Kolios (2010) Study of laser-induced thermoelastic deformation of native and coagulated ex-vivo bovine liver tissues for estimating their optical and thermomechanical properties Journal of Biomedical Optics 15(6) – 065002
  2. Eric M. Strohm, Gregory J. Czarnota, and Michael C. Kolios (2010) Quantitative Measurements of Apoptotic Cell Properties Using Acoustic Microscopy IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 57, no. 10
  3. Roxana M. Vlad, Ratan K Saha, Nehad M. Alajez, Shawn Ranieri, Gregory J. Czarnota and Michael C. Kolios (2010) An increase in cellular size variance contributes to the increase in ultrasound backscatter during cell death  Ultrasound in Medicine and Biology 36 (9) 1546-1558
  4. Omar Falou, Min Rui, Ahmed El Kaffas,  J. Carl Kumaradas and Michael C. Kolios (2010) The measurement of ultrasound scattering from individual micron-sized objects and its application in single cell scatteringThe Journal of the Acoustical Society of America 128 (2) 894–902 [selected for the August 15, 2010 issue of Virtual Journal of Biological Physics Research]
  5. Roxana M. Vlad, Michael C. Kolios, Joanne L. Moseley, Gregory J. Czarnota, Kristy K. Brock (2010) Evaluating the extent of cell death in 3D high frequency ultrasound by registration with whole-mount tumor histopathology Medical Physics 37 (8) 4288-4297 [selected for the August 1, 2010 issue of Virtual Journal of Biological Physics Research]
  6. Ratan K Saha, Subodh K Sharma and Michael C Kolios (2010) Single cell size estimation from backscattered spectrum by using some weak acoustic scattering approximations Canadian Acoustics / Acoustique canadienne 38 (2) 31-34
  7. Gregory J. Czarnota and Michael C. Kolios (2010) Ultrasound detection of cell deathImaging in Medicine 2(1) 17-28

2009

  1. Michael C. Kolios and Gregory J. Czarnota (2009) Potential use of ultrasound for the detection of cell changes in cancer treatment Future Oncology 5(10) 1527-1532
  2. Vlad RM, Brand S, Giles A, Kolios MC, Czarnota GJ. (2009) Quantitative Ultrasound Characterization of Responses to Radiotherapy in Cancer Mouse ModelsClincal Cancer Research 15(6):2067-75
  3. Brand S, Solanki B, Foster DB, Czarnota GJ, Kolios MC. (2009) Monitoring of cell death in epithelial cells using high frequency ultrasound spectroscopy Ultrasound in Medicine and Biology 35(3):482-93

2008

  1. Roxana M. Vlad, Nehad M. Alajez, Anoja Giles, Michael C. Kolios, Gregory J. Czarnota (2008) Quantitative Ultrasound Characterization of Cancer Radiotherapy Effects In Vitro International Journal of Radiation Oncology Biology Physics, 72 (4): 1236-1243
  2. Omar Falou, Ralph E. Baddour, George Nathanael, Gregory J. Czarnota, J. Carl Kumaradas and Michael C. Kolios (2008) A study of high frequency ultrasound scattering from non-nucleated biological specimens The Journal of the Acoustical Society of America 124(5): EL278-EL283 [selected  for inclusion in the Virtual Journal of Biological Physics Research / Volume 16 / Issue 8 / 2008]
  3. Behzad Banihashemi, Roxana Vlad, Bane Debeljevic, Anoja Giles, Michael C. Kolios, Gregory J. Czarnota (2008) Detecting the Effects of Photodynamic Therapy in vivo by High Frequency Ultrasound Spectroscopy: a Novel Way of Monitoring Tumour Response Cancer Research 68(20): 8590-8596
  4. Sebastian Brand, Weiss EC, Lemor RM, and Kolios M.C. (2008) High frequency ultrasound tissue characterization and acoustic microscopy of intracellular changesUltrasound in Medicine and Biology 34(9): 1396-1407

2007

  1. Harshitha Nallapareddy, Sridhar Krishnan and Michael Kolios (2007) Parametric analysis of ultrasound backscatter signals for monitoring cancer cell structural changes during cancer treatment Canadian Acoustics 35(2): 47-54
  2. Ralph E. Baddour, Farhan N. Dadani, Michael C. Kolios and Stuart K. Bisland (2007) High-Frequency Ultrasound Assessment of Antimicrobial Photodynamic Therapy In Vitro Journal of Biological Physics 33:61–66
  3. Linda Taggart, Ralph E. Baddour, Anoja Giles, Gregory J. Czarnota and Michael C. Kolios (2007) Ultrasonic Characterization of Whole Cells and Isolated Nuclei, Ultrasound in Medicine and Biology 33 (3): 389-401
  4. Darren Morofke, Michael C. Kolios, I. Alex Vitkin and Victor X. D. Yang (2007) Wide dynamic range detection of bidirectional flow in Doppler optical coherence tomography using a two-dimensional Kasai estimator Optics Letters 32 (3): 253-255 [Selected for inclusion in the Virtual Journal of Biological Physics Research – Jan 15 2007 issue]
  5. Ralph E. Baddour and Michael C. Kolios (2007) The fluid and elastic nature of nucleated cells: Implications from the cellular backscatter response JASA Express Letters 121 (1): 16-22

2006

  1. Parmar N. and Kolios M.C. (2006) An Investigation of the Use of Transmission Ultrasound to Measure Acoustic Attenuation Changes in Thermal Therapy Medical and Biological Engineering and Computing 44:583-591

2005

  1. A.S. Tunis G.J. Czarnota, A. Giles, M.D. Sherar, J.W. Hunt and M.C. Kolios (2005) Monitoring Structural Changes in Cells with High Frequency Ultrasound Signal Statistics Ultrasound in Medicine and Biology 31(8), 1041-1049
  2. R. E. Baddour, M. D. Sherar, J. W. Hunt, G. J. Czarnota, M. C. Kolios (2005) High-frequency ultrasound scattering from microspheres and single cells Journal of  the Acoustical Society of  America, 117(2), 934-943 [Selected for inclusion in the Virtual Journal of Biological Physics Research – Feb 1 2005 issue]
  3. Roxana M. Vlad; Gregory J. Czarnota; Anoja Giles; Michael D. Sherar; John W. Hunt; Michael C. Kolios (2005) High-frequency ultrasound for monitoring changes in liver tissue during preservation Physics in Medicine and Biology, 50(2) 197-213

2003

  1. Mihaela Pop, Andrea Molckovsky, Lee Chin, Michael C Kolios, Michael A S Jewett and Michael D Sherar (2003) Changes in dielectric properties at 460 kHz of kidney and fat during heating: importance for radio-frequency thermal therapy Physics in Medicine and Biology 48, 2509-2525

2002

  1. Kolios M.C., Czarnota G.J., Lee M. , Hunt J.W. and Sherar M.D. (2002) Ultrasonic spectral parameter imaging of apoptosis Ultrasound in Medicine and Biology 28(5), 589-597
  2. Hunt J.W., Worthington A., Xuan A., Kolios M.C., Czarnota G.J. and Sherar M.D. (2002) A model based upon pseudo-regular spacing of cells combined with the randomization of nuclei can explain the significant changes in high-frequency ultrasound during apoptosis Ultrasound in Medicine and Biology 28(2), 217-226

2000

  1. M. D Sherar, J. A. Moriarty, M.C. Kolios, J.C. Chen, R.D. Peters, L.C. Ang, R.S. Hinks, R.M. Henkelman, M.J. Bronskill, W. Kucharczyk (2000) Comparison of thermal damage calculated using magnetic resonance thermometry with magnetic resonance imaging post treatment and histology after interstitial microwave thermal therapy of rabbit brain Physics in Medicine and Biology 45, 3563-3576
  2. Iizuka M.N., Vitkin A.I., Kolios M.C., Sherar M.D. (2000) The Effects of Dynamic Optical Properties During Interstitial Laser Photocoagulation Physics in Medicine and Biology 45, 1335-1357

1999

  1. Czarnota G.J., Kolios M.C., Abraham J., Portnoy M., Ottensmeyer F.P., Hunt, J.W. and Sherar M.D.(1999) Ultrasonic imaging of apoptosis: high-resolution non-invasive imaging of programmed cell death in vitro, in situ and in vivo British Journal of Cancer 81(3), 520-527
  2. Kolios M.C., Worthington A.E., Holdsworth D.W., Sherar M.D. and Hunt J.W. (1999) An investigation of the flow dependence of temperature gradients near large vessel during steady state and transient tissue heating  Physics in Medicine and Biology 44(6), 1479-1497

1998

  1. Skinner M., Iizuka M., Kolios M.C. and Sherar M.D. (1998) A Theoretical Comparison of Energy Sources: Microwave, Ultrasound and Laser, for Interstitial Thermal Therapy Physics in Medicine and Biology 43(12), 3535-3547
  2. Kolios M.C., Worthington A. E., Sherar M.D. and Hunt J.W. (1998) Experimental evaluation of two simple thermal models using transient temperature analysis Physics in Medicine and Biology 43(11), 3325-3340

1997

  1. Czarnota G.J.* , Kolios M.C.* , Vaziri H.* , Benchimol S., Ottensmeyer F.P., Sherar M.D. and Hunt J.W. (1997) Ultrasonic imaging of viable, dead and apoptotic cells Ultrasound in Medicine and Biology 23(6), 961-965 * authors have made equal contribution
  2. Vitkin I.A., Moriarty J.A., Peters R.D., Kolios M.C., Gladman A.S., Chen J.C., Hinks R.S., Hunt J.W., Wilson B.C., Easty A.T., Bronskill M.J., Kucharczyk W., Sherar M.D. and Henkelman R.M. (1997) Magnetic resonance imaging of temperature changes during interstitial microwave heating: a phantom study Medical Physics 24, 269-277

1996

  1. Kolios M.C., Sherar M.D. and Hunt J.W. (1996) Blood flow cooling and ultrasonic lesion formation Medical Physics 23(7), 1287-98

1995

  1. Kolios M.C., Sherar M.D. and Hunt J.W. (1995) Large vessel cooling in heated tissues: a numerical study Physics in Medicine and Biology 40, 1-18

1992

  1. Lepock J.R., Ritchie K.P., Kolios M.C., Rodahl A.M., Heinz K.A., and Kruuv J. (1992) Influence of transition rates and scan rate on kinetic simulations of differential scanning calorimetry profiles of reversible and irreversible protein denaturation Biochemistry 31(50), 12706-12

BOOK CHAPTERS

  1. Eno Hysi, Eric M. Strohm , Michael C. Kolios (2014) Probing Different Biological Length Scales Using Photoacoustics: From 1 To 1000 MHz Handbook of Photonics for Biomedical Engineering Edited by: Aaron H.-P. Ho, Donghyun Kim, Michael G. Somekh ISBN 978-94-007-6174-2/ DOI 10.1007/978-94-007-6174-2_29-3
  2. Omar Falou, Ali Sadeghi-Naini, Azza Al-Mahrouki, Michael C. Kolios and Gregory J. Czarnota (2013)  Quantitative Ultrasound and Cell Death Quantitative Ultrasound of Soft Tissue Edited by: Jonthan Mamou / Michael L. Oelze © Springer ISBN 978-94-007-6951-9 / ISBN 978-94-007-6952-6 / DOI 10.1007/978-94-007-6952-6
  3. E.M. Strohm, G. Czarnota, M.C. Kolios (2013) Acoustic microscopy of cells Quantitative Ultrasound of Soft Tissue Edited by: Jonthan Mamou / Michael L. Oelze © Springer ISBN 978-94-007-6951-9 / ISBN 978-94-007-6952-6 / DOI 10.1007/978-94-007-6952-6
  4. Vlad RM, Kolios MC, Czarnota GJ. (2011)  Ultrasound imaging of apoptosis: spectroscopic detection of DNA-damage effects at high and low frequencies. Methods in Molecular Biology Volume 682, Part 3, 165-187 Edited by: V. V. Didenko © Humana Press Inc., Totowa, NJ DOI: 10.1007/978-1-60327-409-8_13
  5. Czarnota, G.J. Kolios, M.C. Hunt, J.W. and Sherar, M.D (2002) Ultrasound Imaging of Apoptosis: DNA Damage Visualized in Methods in Molecular Biology, vol. 203: In Situ Detection of DNA Damage: Methods and Protocols Edited by: V. V. Didenko © Humana Press Inc., Totowa, NJ

CONFERENCE PAPERS (PEER REVIEWED)

  1. Kolios M.C., Sherar M.D. and Hunt J.W. (1999) Temperature Dependent Properties and Ultrasound Thermal Therapy In E.P. Scott (Ed.) Advances in Heat and Mass Transfer in Biotechnology HTD-Vol.363 / BED- Vol.44, 113-118. American Society of Mechanical Engineers.
  2. The Effect of Heat Induced Changes in Microwave Tissue Properties on Thermal Therapy for Prostate Cancer Sherar M.D., Chin, L. Kolios M.C. and Gladman, A.S. (1999) In E.P. Scott (Ed.) Advances in Heat and Mass Transfer in Biotechnology HTD-Vol.363 / BED-Vol.34, 109-112. American Society of Mechanical Engineers.
  3. Monitoring tissue response to photodynamic therapy: The potential of minimally invasive electrical impedance spectroscopy and high frequency ultrasound Wilson B.C., Molckovsky A., Czarnota G.J., Sherar M.D., Kolios M.C. Lilge, L. Dattani R.S., Osterman K.S., Paulsen K.D., Hoopes P.J. (1999) In S.L. Jacques (Ed.) Proceedings of the 1999 SPIE, Vol. 3592 , 73-82.
  4. Kolios M.C., Sherar M.D. and Hunt J.W. (1995)  Thermal model predictions of ultrasonic lesion formation  ( Postscript file, better font) In L.J. Hayes (Ed.), Advances in Bioheat and Mass Transfer in Biotechnology , HTD-Vol.322 / BED-Vol.32, 139-144. American Society of Mechanical Engineers.
  5. Kolios, M.C. Sherar, M.D Worthington, A. E. and Hunt, J.W. (1994)Modeling temperature gradients near large vessels in perfused tissues(Postscript file, better font) In M. Ebadian and P. Oosthuizen (Eds.), Fundamentals of Biomedical Heat Transfer, HTD-Vol. 295, 23-30. American Society of Mechanical Engineers.

CONFERENCE PAPERS (NON PEER-REVIEWED)

         2017

    1. Application of image flow cytometry for the characterization of red blood cell morphology
      Ruben N. Pinto; Joseph A. Sebastian; Michael Parsons; Tim C. Chang; Jason P. Acker; Michael C. Kolios
      Proc. SPIE 10076, High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management II, 100761F (22 February 2017); doi: 10.1117/12.2253583
    2. Photoacoustic measurements of red blood cell oxygen saturation in blood bags in situ
      Ruben N. Pinto ; Karan Bagga ; Alexandre Douplik ; Jason P. Acker ; Michael C. Kolios
      Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006440 (March 3, 2017); doi:10.1117/12.2253530
    3. Multispectral photoacoustic bioimaging using low power continuous wave lasers
      K. Sathiyamoorthy Eric M. Strohm and Michael C. Kolios
      Proc. of SPIE Vol. 10064  100644M-1 doi: 10.1117/12.2252598
    4. Rapid computation of photoacoustic fields from normal and pathological red blood cells using a Green’s function method
      Ratan K. Saha, Muhannad N. Fadhel, Aamna Lawrence, Subhajit Karmakar, Arunabha Adhikari, and Michael C. Kolios
      Proc.of SPIE Vol. 10064, 100644U  doi: 10.1117/12.2253555
    5. Spatial interference encoding patterns based super resolved photoacoustic microscopy
      Amihai Meiri, Eric M. Strohm, Michael C. Kolios and Zeev Zalevsky
      Proc. of SPIE Vol. 10064, 1006453 doi: 10.1117/12.2251675
    6. Quantitative photoacoustic assessment of red blood cell aggregation under pulsatile blood flow: experimental and theoretical approaches
      Tae-Hoon Bok, Eno Hysi, Michael C. Kolios
      Proc.of SPIE Vol. 10064, 100645F doi: 10.1117/12.22502212016
    7. Single red blood cell oxygenation saturation imaging with multispectral photoacoustic microscopy
      Moore, M.J.,  Schygulla, P.M.,  Strohm, E.M.,  Kolios, M.C.
      2016 IEEE International Ultrasonics Symposium; DOI: 10.1109/ULTSYM.2016.7728869
    8. High frequency ultrasound imaging and spectral analysis of sea urchin oocytes
      Strohm, E.M.,  Wirtzfeld, L.A.,  Czarnota, G.J.,  Kolios, M.C.
      2016 IEEE International Ultrasonics Symposium; DOI: 10.1109/ULTSYM.2016.7728710
    9. High frequency photoacoustic spectral analysis of erythrocyte programmed cell death (eryptosis)
      Fadhel, M.N.,  Strohm, E.M.,  Kolios, M.C.
      2016 IEEE International Ultrasonics Symposium; DOI: 10.1109/ULTSYM.2016.7728865
    10. Ultrasound and photoacoustic analysis of cell pellets at 200 MHz
      Wirtzfeld, L.A.,  Strohm, E.M.,  Kolios, M.C.
      2016 IEEE International Ultrasonics Symposium; DOI: 10.1109/ULTSYM.2016.7728644
    11. Steering the receiving field of view (FOV) without applying delays insynthetic transmit aperture imaging (STA)
      Li, Y.,  Kolios, M.C.,  Xu, Y.
      2016 IEEE International Ultrasonics Symposium; DOI: 10.1109/ULTSYM.2016.7728492
    12. Plane-wave imaging using synthetic aperture imaging reconstruction technique with regularized singular-value decomposition (RSVD)
      Li, Y.,  Yang, D-M, Kolios, M.C.,  Xu, Y.
      2016 IEEE International Ultrasonics Symposium; DOI: 10.1109/ULTSYM.2016.7728888
    13. Differentiation between cellularized and decellularized mouse kidneys using mean scatterer spacing: A preliminary study
      Remie Nasr; Omar Falou; Eno Hysi; Lauren Wirtzfeld; Elizabeth S. L. Berndl; Michael C. Kolios
      3rd Middle East Conference on Biomedical Engineering (MECBME); DOI: 10.1109/MECBME.2016.7745422
    14. Photoacoustic investigation of gold nanoshells for bioimaging applications
      K. Sathiyamoorthy ; Eric M. Strohm and Michael C. Kolios
      Proc. SPIE 9724, Plasmonics in Biology and Medicine XIII, 97240L (March 7, 2016); doi:10.1117/12.2213766
    15. Large-pitch steerable synthetic transmit aperture imaging (LPSSTA)
      Ying Li ; Michael C. Kolios and Yuan Xu
      Proc. SPIE 9790, Medical Imaging 2016: Ultrasonic Imaging and Tomography, 97901Y (April 1, 2016); doi:10.1117/12.2216908
    16. One-layer microfluidic device for hydrodynamic 3D self-flow-focusing operating in low flow speed
      Yasaman Daghighi ; Vaskar Gnyawali ; Eric M. Strohm ; Scott S. H. Tsai and Michael C. Kolios
      Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970505 (March 18, 2016); doi:10.1117/12.2212892
    17. Measuring intracellular motion in cancer cell using optical coherence tomography
      Azhar Zam and Michael C. Kolios
      Proc. SPIE 9707, Dynamics and Fluctuations in Biomedical Photonics XIII, 97070V (March 17, 2016); doi:10.1117/12.2209652
    18. Classification of biological cells using a sound wave based flow cytometer
      Eric M. Strohm ; Vaskar Gnyawali ; Mia Van De Vondervoort ; Yasaman Daghighi ; Scott S. H. Tsai and Michael C. Kolios
      Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97081A (March 15, 2016); doi:10.1117/12.2211740
    19. Acoustic and photoacoustic microscopy imaging of single leukocytes
      Eric M. Strohm ; Michael J. Moore and Michael C. Kolios
      Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97082G (March 15, 2016); doi:10.1117/12.2211759
    20. Photoacoustic spectral analysis to sense programmed erythrocyte cell death (eryptosis) for monitoring cancer response to treatment
      Muhannad N. Fadhel ; Fayruz Kibria and Michael C. Kolios
      Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97080O (March 15, 2016); doi:10.1117/12.2211760
    21. Simultaneous photoacoustic and optical attenuation imaging of single cells using photoacoustic microscopy
      Michael J. Moore ; Eric M. Strohm and Michael C. Kolios
      Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970850 (March 15, 2016); doi:10.1117/12.2212961
    22. Biodegradable polymer based theranostic agents for photoacoustic imaging and cancer therapy
      Yan J. Wang ; Eric M. Strohm and Michael C. Kolios
      Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970826 (March 15, 2016); doi:10.1117/12.2212999
    23. Effect of optical wavelength on photoacoustic investigations of pulsatile blood flow
      Tae-Hoon Bok ; Eno Hysi and Michael C. Kolios
      Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97081M (March 15, 2016); doi:10.1117/12.2212108
    24. Photoacoustic simulation of microvessel bleeding: spectral analysis and its implication for monitoring vascular-targeted treatments
      Muhannad N. Fadhel ; Eno Hysi ; Jason Zalev and Michael C. Kolios
      Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97081B (March 15, 2016); doi:10.1117/12.2211774
      2015
    25. Evaluation of the Morphological Parameters of Cancer Cells Using High-Frequency Ultrasound and Photoacoustics
      Michael J. Moore, Eric M. Strohm, and Michael C. Kolios
      In 2015 IEEE International Ultrasonics Symposium Proceedings – 10.1109/ULTSYM.2015.0246
    26. Low Power Continuous Wave Photoacoustic Microscope for Bioimaging Applications
      K. Sathiyamoorthy and Michael C. Kolios
      In 2015 IEEE International Ultrasonics Symposium Proceedings – 10.1109/ULTSYM.2015.0398
    27. Nonlinear Model of Acoustical Attenuation and Speed of Sound in a Bubbly Medium.
      Amin Jafari Sojahrood, Hossein Haghi, Raffi Karshafian, Michael C. Kolios
      In 2015 IEEE International Ultrasonics Symposium Proceedings – 10.1109/ULTSYM.2015.0086
    28. Reducing the Number of Receiving Channels Using Transmit-Receive Symmetry in Synthetic Transmit Aperture Imaging
      Ying Li, Ping Gong, Michael C. Kolios, Yuan Xu
      In 2015 IEEE International Ultrasonics Symposium Proceedings -10.1109/ULTSYM.2015.0306
    29. Simulation Studies of Filtered Spatial Compounding (FSC) and Filtered Frequency Compounding (FFC) in Synthetic Transmit Aperture (STA) Imaging
      Ping Gong, Michael C. Kolios, Yuan Xu
      In 2015 IEEE International Ultrasonics Symposium Proceedings -10.1109/ULTSYM.2015.0197
    30. Ultrasonic Characterization of Extra-Cellular Matrix in Decellularized Murine Kidney and Liver
      L. A. Wirtzfeld, E. S. L. Berndl, M. C. Kolios
      In 2015 IEEE International Ultrasonics Symposium Proceedings – 10.1109/ULTSYM.2015.0170
    31. Probing the in vivo changes in oxygen saturation with photoacoustic imaging as a non-invasive means of assessing treatment progression
      Eno Hysi, Jonathan P. May, Lauren Writzfeld, Elijus Undyzs, Shyh-Dar Li, Michael C. Kolios
      Proc. of SPIE Vol. 9323, 93231Z (doi: 10.1117/12.2080372)
    32. High-frequency photoacoustic imaging of erythrocyte aggregation and oxygen saturation: probing hemodynamic relations under pulsatile blood flow
      Tae-Hoon Bok, Eno Hysi, Michael C. Kolios
      Proc. of SPIE Vol. 9323, 93231Q (doi: 10.1117/12.2076650)
    33. Gold-nanoshells as surface plasmon resonance (SPR)
      K. Sathiyamoorthy and Michael C. Kolios
      Proc. of SPIE Vol. 9332, 93320G (doi: 10.1117/12.2080303)
    34. Numerical investigation of plasmonic properties of gold nanoshells
      K. Sathiyamoorthy and Michael C. Kolios
      Proc. of SPIE Vol. 9340, 93400V (doi: 10.1117/12.2080428)
    35. Realistic photoacoustic image simulations of collections of solid spheres using linear array transducer
      Subhajit Karmakar, Eno Hysi, Michael C. Kolios and Ratan K. Saha
      Proc. of SPIE Vol. 9323, 932339 (doi: 10.1117/12.2080794)
    36. Multifunctional perfluorocarbon nanoemulsions for cancer therapy and imaging
      Donald A. Fernandes, Dennis D. Fernandes, Yan J. Wang, Yuchong Li, Claudiu C. Gradinaru, Dérick Rousseau, Michael C. Kolios
      Proc. of SPIE Vol. 9338, 93380R (doi: 10.1117/12.2079914)
    37. Mean scatterer spacing estimation from pellets using cepstral analysis: A preliminary study
      Remie Nasr, Omar Falou, Lauren Wirtzfeld, Elizabeth Berndl and Michael Kolios
      2015 International Conference on Advances in Biomedical Engineering (ICABME) Article number 7323313, Pages 305-308 (doi:10.1109/ICABME.2015.7323313)
    38. Photoacoustic speckle and spectral analysis of vasculature trees
      Muhannad Fadhel, and Michael C. Kolios
      IFMBE Proceedings World Congress on Medical Physics and Biomedical Engineering Volume 51, 2015, Pages 1084-1087 (DOI: 10.1007/978-3-319-19387-8_264)2014

 

 

 

 

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